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Bioanalytical Scientist (m/w/d) for Oligonucleotide Drugs in BioX Chapter: Cellular and Soluble Biomarkers and Bioanalytics

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31.01.2023 100% Festanstellung
1201 F. Hoffmann-La Roche AG
Bioanalytical Scientist (m/w/d) for Oligonucleotide Drugs in BioX Chapter: Cellular and Soluble Biomarkers and Bioanalytics
The Position

Bioanalytical Scientist (m/w/d) for Oligonucleotide Drugs in BioX Chapter: Cellular and Soluble Biomarkers and Bioanalytics

In Roche's Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world's toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located in the Roche Innovation Center Basel and anchored into a chapter within the Pharmaceutical Sciences (PS) function, where the development of regulatory compliant assays for Biomarkers and Bioanalytics is a primary focus. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

The position holder will be member of the newly formed cross-functional RNAHub, where disease-biologists, nonclinical development experts, molecular biologists, molecule engineers, bioengineers and data scientists from various pRED functions join together to create and apply technologies that perturb RNA to discover drugs, biomarkers and targets.

The RNAHub takes a very data-centric approach, utilizing both artificial and human intelligence, that requires a high degree of data-literacy. In the RNAHub, we build a strong, collective and engaged community, where we employ, explore and evolve new ways of working in a research environment.

Job mission

Being an expert for the development of bioanalytical assays and biomarkers required for the development of oligonucleotides, your main responsibilities are the evaluation and application of novel methodologies to drive scientific innovation in the field. You work with other scientists and associates in the lab to support the development of oligonucleotides from discovery to early development. Within the RNAHub you act as a Project Representative for all Discovery Projects of that therapeutic modality.

Your impact

? You have expert knowledge in the field of oligonucleotide development and methods toanalyze the PK and selected PD aspects of a therapeutic compound and itsbiodistribution.

? You are aware of the requirements for the pre-clinical and clinical development ofoligonucleotides and help to evolve the chapter to an industry-leading expertise in thefield of bioanalysis and biomarker development for that therapeutic modality.

? You are keen to apply the technologies in the lab, train others in the application of new technologies in the area and help to transfer novel methods to external collaborationpartners.

? You act as a representative for the Bioanalytical and Biomarker Chapter for all discovery projects dealt by the RNA Hub and support their development.

Your profile

? PhD in Biology, Chemistry, Pharmacy, or similar or MSc with significant experience

? 5+ years experience from academia or industry in the development of bioanalytical / biomarker methods to support oligonucleotide drug development.

? Profound background in molecular biology and hands-on experience with relevanttechnologies; in-depth knowledge of quantitative LC-MS methods is a must.Knowledgeof ELISA and of qPCR-based platform (e.g. molPCR) is a plus.

? Expert knowledge in tissue sample preparation and processing as well as indevelopment of an appropriate quality control concept.

? Sound experience and practical knowledge of the procedures to procure and managebioanalytical services at external providers (CROs).

? High spirit of collaboration and ability to work in a highly self-managed manner in anagile matrix team with a sense of urgency and ability to deal with complex situations.

? You are able to scientifically mentor and lead people in a matrix setting.

? You exhibit a growth mindset. You ask for feedback and act on it. You embraceopportunities to gain new skills and perspectives and provide honest feedback to othersto help them grow

Hiring Location: Basel

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

Über die Firma

5,0 (1 Bewertung)

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