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Postdoctoral Research Fellow in Microbiota & Intestinal Immunity / Immunopathology

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Postdoctoral Research Fellow in Microbiota & Intestinal Immunity / Immunopathology

Postdoctoral Research Fellow in Microbiota & Intestinal Immunity / Immunopathology

Epithelia provide a physical barrier between the body and the environment, which is under the constant challenge from commensals and pathogens. Persistent dysbalance of the epithelial barrier promotes inflammatory diseases or cancer development. In this project, we will use mouse models to study the role of mRNA splicing for the homeostasis and the integrity of the epithelial barrier, particularly in the intestine (Mager et al., eLife 2017; Thoo L et al., Cell Death Dis. 2019). In particular, we will investigate how mRNA splicing influences the crosstalk of epithelial cells with immune cells and the microbiota. To evaluate the clinical relevance of the findings generated in the murine models, we will perform translational studies using specimens from human patients with inflammatory bowel disease (IBD) or (intestinal) cancer.

Methodologies utilized in this project include immunological and molecular biology techniques, RNA sequencing, in vitro assays (e.g. ELISA, stimulation assays with intestinal bacteria), cell culture and histology, which will be applied in mouse models or specimens from IBD or colorectal cancer patients. Bioinformatic analysis will be required for parts of the project, but this will be mainly done with the help of collaborators.

This project will provide multiple opportunities for collaborations and cross-disciplinary scientific exchanges. The candidate will have access to state-of-the-art scientific equipment in immunology and core facilities for flow cytometry, confocal microscopy, a germ-free and gnotobiotic mouse facility, and will receive support from an in-house Translation Research Unit (TRU) for histology and obtaining patient-derived samples https://www.pathology.unibe.ch/index_eng.html

We are looking for a strongly motivated candidate with a PhD or MD/PhD degree, with experience in multi-color flow cytometry, gene expression analyses and work with murine models. Additional expertise for microbiota analyses and microbiology would be highly desirable. The candidate should be proactive, have excellent communication skills (also in English), possess an aptitude to work independently, and particularly drive and maintain multi-departmental collaborations. This position is a unique opportunity to liaise with multi-disciplinary experts and be at the forefront of a topic that is quickly evolving.

If your profile matches our requirements, we look forward to receiving your application. The single PDF file should include: a 1-page motivation letter specifying your experience and personal attributes for this position (please include desired start date), CV, copies of PhD or MD/PhD degree, list of publications, and the names and telephone numbers of three referees to Philippe Krebs (philippe.krebs@pathology.unibe.ch). The position will remain open until a suitable candidate will be recruited.

Our group offers a well-funded research project in a young and dynamic environment. The group is a tight unit dedicated to supporting each other. Bern, the capital of Switzerland, is located very close to the Swiss Alps and is well connected to many important European cities (Zürich, Paris, Milan and Munich). The salary will be according to the standards of the University of Bern. The position is limited to 2 years with a possibility of extension.

Contact person for further details:
Philippe Krebs, PhD
philippe.krebs@pathology.unibe.ch
Telephone: +41 31 632 4971

Institut of Pathology - Research Groups

Bern / Lausanne / Biel/Bienne

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