Snr Principal Scientist Translational Research/Immunology (80-100%*)
About the Role
Location: Basel, Switzerland
Full time, onsite, #LI-Onsite
The Immunology Department (IMM-DA) at Novartis has a strong track record in discovery and development of novel therapies for the treatment of autoimmune and inflammatory diseases.
We are looking for an experienced Immunologist for our Translational Research (TR) group. The TR group is an integrated group of scientists with strong expertise in in vivo Pharmacology, Molecular Pathology, disease-relevant in vitro models, and Data Science. The TR group conducts preclinical experiments and uses patient data and human biosamples to support the compound portfolio of IMM-DA end-to-end.
The candidate will lead a lab and generate key translational insights on the next wave of therapies for patients with autoimmune and inflammatory diseases. The ideal candidate will have a strong background in preclinical in vivo pharmacology and will closely collaborate with the other disciplines in the TR group to successfully advance novel therapies into the clinics. Industry experience in drug discovery of biologic and low molecular weight therapies is of advantage.
Responsibilities:
• Generate preclinical in vivo and translational data in support of key portfolio projects.
• Address key translational research questions for novel drugs related to mechanisms of action, asset differentiation, in vivo PK/PD relationship and exploratory biomarkers from animal studies and/or patient samples.
• Represent TR on program discovery and development teams. Lead a target discovery effort or drug discovery project from a translational perspective. Contribute to the overall department’s strategic direction with special focus on increasing the impact of translational research approaches in drug discovery and development.
• Lead internal and external collaborations to increase team capabilities or address a strategic need.
• Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution.
• Prepare and/or direct the preparation and review of Preclinical Pharmacology sections of IBs, INDs, abstracts, and manuscripts.
Full time, onsite, #LI-Onsite
The Immunology Department (IMM-DA) at Novartis has a strong track record in discovery and development of novel therapies for the treatment of autoimmune and inflammatory diseases.
We are looking for an experienced Immunologist for our Translational Research (TR) group. The TR group is an integrated group of scientists with strong expertise in in vivo Pharmacology, Molecular Pathology, disease-relevant in vitro models, and Data Science. The TR group conducts preclinical experiments and uses patient data and human biosamples to support the compound portfolio of IMM-DA end-to-end.
The candidate will lead a lab and generate key translational insights on the next wave of therapies for patients with autoimmune and inflammatory diseases. The ideal candidate will have a strong background in preclinical in vivo pharmacology and will closely collaborate with the other disciplines in the TR group to successfully advance novel therapies into the clinics. Industry experience in drug discovery of biologic and low molecular weight therapies is of advantage.
Responsibilities:
• Generate preclinical in vivo and translational data in support of key portfolio projects.
• Address key translational research questions for novel drugs related to mechanisms of action, asset differentiation, in vivo PK/PD relationship and exploratory biomarkers from animal studies and/or patient samples.
• Represent TR on program discovery and development teams. Lead a target discovery effort or drug discovery project from a translational perspective. Contribute to the overall department’s strategic direction with special focus on increasing the impact of translational research approaches in drug discovery and development.
• Lead internal and external collaborations to increase team capabilities or address a strategic need.
• Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution.
• Prepare and/or direct the preparation and review of Preclinical Pharmacology sections of IBs, INDs, abstracts, and manuscripts.
Role Requirements
What you will bring to the role:
• Ph.D. or MD/PhD with PostDoc in Immunology, Pharmacology, or related discipline plus >5 years of professional experience in academia or industry.
• Expert understanding of in vivo disease models and experience in performing mechanistic studies in rodent models of autoimmune and inflammatory diseases is required.
• Immunology/autoimmune disease knowledge, including target and mechanism knowledge (e.g. SLE, arthritis, atopic dermatitis) and awareness of clinical standard of care.
• Understanding of fundamentals and practice of the drug discovery process in pharma industry is of advantage.
• Excellent written and oral communication skills.
• Self-motivated and collaborative, with excellent time management and interpersonal skills.
Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our
people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more he re: https://www.novartis.com/about/strategy/people and culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits rewards
communities we serve.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to Write an email and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
• Ph.D. or MD/PhD with PostDoc in Immunology, Pharmacology, or related discipline plus >5 years of professional experience in academia or industry.
• Expert understanding of in vivo disease models and experience in performing mechanistic studies in rodent models of autoimmune and inflammatory diseases is required.
• Immunology/autoimmune disease knowledge, including target and mechanism knowledge (e.g. SLE, arthritis, atopic dermatitis) and awareness of clinical standard of care.
• Understanding of fundamentals and practice of the drug discovery process in pharma industry is of advantage.
• Excellent written and oral communication skills.
• Self-motivated and collaborative, with excellent time management and interpersonal skills.
Why Novartis:
Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our
people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more he re: https://www.novartis.com/about/strategy/people and culture
You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits rewards
communities we serve.
Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to Write an email and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external)
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