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Protein Scientist

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AMAL Therapeutics is a biotech developing unique therapeutic vaccines, and a distinct unit of the Discovery Research organization of the Boehringer Ingelheim group.

The company has developed a novel peptide/protein-based immunization technology platform, so-called KISIMA®, with the aim of stimulating the patient’s immune system for effective anti-cancer therapy. AMAL’s lead product, ATP128, is in clinical development for metastatic colorectal cancer since July 2019.

The company is currently seeking a highly motivated candidate covering the functions detailed below.

Protein Scientist

AMAL Therapeutics is a biotech developing unique therapeutic vaccines, and a distinct unit of the Discovery Research organization of the Boehringer Ingelheim group.

The company has developed a novel peptide/protein-based immunization technology platform, so-called KISIMA®, with the aim of stimulating the patient’s immune system for effective anti-cancer therapy. AMAL’s lead product, ATP128, is in clinical development for metastatic colorectal cancer since July 2019.

The company is currently seeking a highly motivated candidate covering the functions detailed below.


Key Responsibilities

  • Design, execute and evaluate protein expression experiments for screening, manufacturability assessment, process development and preclinical research
  • Characterize and optimize protein expression in bacterial host strains
  • Design and implement purification strategies
  • Perform solubility screening
  • Assess protein quality by analytical characterization
  • Manage protein production workflow and supplies in 2-50 mg scale
  • Operating and maintaining high-performance liquid chromatography systems and lab equipment
  • Manage inventories and working material stocks
  • Interpretation of results and data analysis
  • Communicate results effectively to collaborators and to the project team
  • Make presentations for internal and external audience
  • Write study plans, SOPs, study reports
  • Manage a laboratory-based team
  • Project management, including weekly planification of activities
  • Review of analytical procedures and assay validation/qualification reports
  • Management of the CMC activities, including ongoing stability studies and DP shelf-life assignment
  • Maintaining records of all CMC relevant documentation
  • Monitoring of out-sourced manufacturing activities (CMO, bioassays, labelling/packaging activities)
  • Sample shipment organization, tracking and documentation
  • Writing and review CMC sections for regulatory submissions

Your profile

  • PhD in Biological Sciences/Biological Engineering or related field (biotechnology, pharmacy, biochemistry, chemical engineering, biology etc.)
  • Experience in the field of recombinant protein expression, formulation and protein analytics
  • Team player with strong motivation, interpersonal skills and excellent communication abilities
  • Flexible, open for new ideas and tasks, high willingness to learn, troubleshooting oriented, hands-on
  • Excellent organizational skills and ability to adapt

Adresse

Avenue de la Roseraie 64 c/o Fondation Recherches Médicales 1205 Genève

Website http://www.amaltherapeutics.com

1205 Genève / Genève

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