Roche Postdoctoral Fellowship (RPF) Researcher visualizing ultrastructures related to Alzheimer’s Disease with Electron Microscopy
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The Roche Postdoctoral Fellowship (RPF) Program has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world.
One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals if necessary preceded by priority patent applications.
We are looking for a talented and enthusiastic postdoctoral scientist to join our electron microscopy team in pRED at Roche in Basel, Switzerland. The mission is dedicated to the visualization of human brain pathology, as well as the isolation and representation of pathologic inclusions that underlie Alzheimer’s Disease. This mission embeds in a highly collaborative industrial research environment and will bridge our discovery efforts with disease-relevant insights gathered with methods and preparative tricks established at the EPFL in Lausanne, Switzerland. It is a project at the interface between outstanding groups at EPFL and Roche, with the work location split between Basel and Lausanne.
You will join a vibrant multicultural team of scientists, associates, postdocs and students working towards innovative approaches for drug discovery in the nervous system.
You have studied Biochemistry, Neurobiology, Neuroscience, Life Science, Medical Biology, Biophysics/Physics or Nanosciences and completed your PhD not longer than 4 years ago.
Your PhD thesis focused on high-resolution cryogenic Transmission Electron Microscopy and included the structure determination of helical filaments, as well as their inspection in cryogenically preserved human brains.
You know how to fixate and preserve brain tissue for analysis with electron microscopy with resin embedding techniques, as well as cryogenic preservation methods.
You have hands-on experience with multiscale imaging techniques, and you have employed immunohistochemistry to find relevant target structures in cryopreserved tissue for structure determination with Transmission Electron Microscopy.
You have a fundamental understanding of the human brain anatomy, as well as the microstructure of neurons and cells in tissue.
Correlative Light Electron Microscopy, CEMOVIS, cryo-FIB-SEM, Electron Tomography are routine methods for you.
You enjoy exploring and applying novel technologies and preparation techniques to extract and isolate structures from tissue (laser micro capturing and related methods).
You are well-trained on and routinely employ digital analysis tools for image analysis, including the 3D reconstruction of helical protein structures.
You are someone who is driven by the desire to find therapeutics for some of the most complicated and devastating disorders. You enjoy teamwork, diligence and efficiency. Working in a multicultural environment motivates you.
You have been actively engaged in scientific research continuously since your PhD and ready to start an RPF postdoctoral activity no later than 4 years after PhD completion.
The duration of the RPF project is initially set fortwo years, with the possibility of extension for a third year. This position is sponsored by the Roche Postdoctoral Fellowship Program. The collaborative research project will be conducted at both Roche Basel sites and at EPFL in Lausanne.
The planned start date of this fellowship is October 2024. Please clearly indicate your preferred starting date on your motivation letter.
All applicants need to include a CV, motivation letter, a publication list and, if available, your PhD certificate.
More information about the RPF Program:
https://careers.roche.com/global/en/the-roche-postdoctoral-fellowship-programme
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