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Research Technician / Scientific Associate - Chemistry Process R&D

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Idorsia Pharmaceuticals Ltd
Research Technician / Scientific Associate - Chemistry Process R&D

For our Chemistry Process R&D organization, we are seeking a motivated Research Technician or Scientific Associate.

Job Responsibilities

  • Carrying out laboratory work ranging from route finding to multi-kilogram syntheses 
  • Optimizing reactions (1-100 g) by scrupulous control of reaction parameters using double-jacketed glass reactors 
  • Proposing alternative reaction conditions and synthesis pathways, and solve scale-up problems
  • Producing Active Pharmaceutical Ingredients (API) on kilogram scale (up to 30-liter reactors) to support preclinical development 
  • Monitoring reaction progress and performing compound analysis using TLC, LC/MS, GC/MS, NMR, or online techniques
  • Interpret analytical data and take appropriate action
  • Purify reaction products using standard techniques e.g. column chromatography, prep. HPLC, crystallization, or distillation 
  • Performing general lab duties and maintain a high standard of order and cleanliness 
  • Equipment champion of a dedicated technology or equipment
  • Accurate and regular documentation of experimental work using electronic lab journal 
  • Summarizing the weekly progress
  • Drafting of Mater Operation Records (MOR)
  • Ownership of parts of projects, like proposal of alternative routes for scale-up, or byproduct and impurity identification
  • Present at internal meetings 

Candidate's Requirements

  • Apprenticeship as laboratory technician or higher education (BSc, MSc), specialized in organic synthesis
  • Excellent skills in synthetic organic chemistry including asymmetric syntheses, reaction monitoring, work-up, analysis including online monitoring, and isolation techniques 
  • Routine use of modern methods to purify and characterize organic compounds (e.g. column chromatography, automated column chromatography, HPLC, LC-MS, NMR, GC, etc.)
  • 1-5 years of operative experience with scale-up of chemical processes preferred (kilo lab or pilot plant scale)
  • Ability to plan and accurately document practical work
  • Safety first attitude, compliance with process safety best practice
  • Team player with good communication skills and play-to-win attitude
  • Hands-on in the lab with problem-solving skills
  • Flexibility for changing work assignments 
  • Fluent in English, both written and oral, and good knowledge of German

What Idorsia offers

  • Exciting opportunities for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits

Work Location: Allschwil

Country: Switzerland

Business Unit: Chemistry - Chemistry Process R&D

Schedule: Fulltime

Job Type: Permanent

Job ID: 2652

Allschwil / Basel area - Allschwil / Switzerland / CH-4123 Allschwil

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