Postdoctoral position in Immunology/Cancer Immunotherapy
The research group led by Dr. Prof. Beltra is currently seeking a highly motivated postdoctoral researcher with a strong interest in conducting high level research in the fields of T-cell immunobiology and cancer immunotherapy. This position will be based in the Department of Biomedicine (https://biomedizin.unibas.ch/en/) in Basel, Switzerland - one of the world's leading locations for life sciences, home to several companies and institutions.
Prof. Beltra's group is studying the factors governing T-cell differentiation programs in settings of viral infections and cancers. Notably, our group is particularly interested in identifying new pathways regulating the process of CD8 T cell exhaustion, an hypofunctional program acquired by CD8 T cells exposed to persistent inflammation and antigenic stimulation. Indeed, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential of current cancer immunotherapies (e.g. PD-1-based therapy). Using state-of-the arts murine models combined to cutting-edge technologies (single cell omics, ATACseq) and innovative immunological and genetic perturbation tools (Retroviruses, CRISPR), our group works on identifying new strategies for a better therapeutic manipulation of exhausted CD8 T cells. Collectively, our group aims to lay the foundation for advancing next-generation cancer immunotherapies.
- Planning, designing, and executing experiments including experiments involving mice.
- Analyzing, structuring, and presenting data.
- Developing collaborative projects.
- Mentoring Ph.D. students.
- Handling mouse colonies and developing original transgenic mouse strains.
- Participating in common lab tasks.
- Applying for fellowships and other grants.
- Preparation of scientific reports, meetings, and journal articles.
- Communicating science at local and international meetings.
- Ph.D. in Immunology, cancer immunobiology, genetics or related fields.
- Demonstrated expertise (peer-reviewed publications) in the fields of immunology, T-cell immunobiology, cancer immunobiology and/or cancer immunotherapy - Required
- Extensive experience in basic immunology techniques (flow cytometry, T-cell based assays) - Required
- Trained for mouse work (handling, injections, tissue harvest) - Required
- Demonstrated expertise using CRISPR-based approaches - Required
- Proficient with basic lab techniques (cell culture, working in sterile conditions).
- Knowledge in next-generation sequencing techniques and data analysis is considered a plus.
- Excellent written and communication skills.
- Fluency in French or English - Required.
Please use the link below to apply and submit the following documents: CV (including list of publications), Cover letter with brief description of past achievements and interests (1 page max), and contact for at least 2 referees including the Ph.D. mentor.
4001 Basel
Adresse
Universität Basel